Temazepam Product Details
Temazepam – Scientific Reference Overview
Chemical Name & Structure
- Chemical Name: 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- Molecular Formula: C16H13ClN2O2
- Molecular Weight: 300.74 g/mol
Structure:
Temazepam is a 1,4-benzodiazepine derivative featuring a chlorinated benzene ring and a hydroxyl functional group that influences its pharmacokinetic properties.
Scientific / Research Context
Temazepam is primarily studied in GABAergic neuropharmacology, where it is used to understand:
- GABA-A receptor modulation
- Sedative-hypnotic mechanism research
- Benzodiazepine structure-activity relationships (SAR)
- Sleep regulation and CNS depression models
- Metabolism of benzodiazepine-class compounds
It is classified as a short-to-intermediate acting benzodiazepine in clinical literature.
Analytical Identification
Common laboratory methods include:
- LC-MS/MS (liquid chromatography–tandem mass spectrometry)
- GC-MS (gas chromatography–mass spectrometry)
- HPLC (high-performance liquid chromatography)
- NMR spectroscopy for structural confirmation
CAS Number
- CAS Number: 846-50-4
Safety & Handling (Laboratory Context)
Temazepam is associated with CNS depressant activity and is handled under strict laboratory controls.
Key precautions:
- Use only in licensed or institutional laboratories
- Wear PPE (gloves, lab coat, eye protection)
- Avoid inhalation, ingestion, or skin contact
- Store in a controlled, secure chemical storage environment
- Follow institutional controlled-substance protocols
Regulatory Status
- Controlled prescription medicine in most jurisdictions
- Regulated under benzodiazepine scheduling laws
- Subject to strict handling, storage, and reporting requirements
Research Importance
Temazepam is used in scientific contexts to better understand:
- Sleep architecture and sedation pathways
- GABA receptor pharmacology
- CNS depressant classification systems
- Metabolic pathways of benzodiazepines