Oxycodone (Powder Form) – Scientific Overview

Chemical Name & Structure

• Chemical Name: (5R,9R,13S,14S)-4,5-epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.37 g/mol
• CAS NUMBER: 76-42-6

Structure:

Oxycodone is a semi-synthetic opioid derived from thebaine. It belongs to the morphinan class and contains a 4,5-epoxy bridge, a 3-methoxy group, and a 14-hydroxy substitution that influences receptor binding affinity.

Scientific / Research Context

Oxycodone is primarily studied in:

• Opioid receptor pharmacology (mu-opioid receptor agonism)
• Pain pathway neurobiology
• CNS depressant mechanism research
• Metabolism and CYP450 enzyme interaction studies
• Controlled substance analytical detection (toxicology screening)

It is a highly regulated Schedule II controlled opioid in most jurisdictions due to its strong activity at opioid receptors and significant risk profile.

Analytical Information (Reference Use)

• CAS Number: 76-42-6
• Common analytical techniques:
  • GC-MS (Gas Chromatography–Mass Spectrometry)
  • LC-MS/MS (Liquid Chromatography–Tandem MS)
  • HPLC (High-Performance Liquid Chromatography)

Safety & Toxicology Profile

Oxycodone is a potent central nervous system depressant.

Key documented risks include:

• Respiratory depression
• High dependence liability
• Tolerance and physical dependence development
• CNS sedation and cognitive impairment
• Fatal overdose risk, especially with other depressants

It is strictly handled under controlled laboratory, clinical, or forensic conditions depending on jurisdiction.

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